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KMID : 0378019900330010099
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New Medical Journal
1990 Volume.33 No. 1 p.99 ~ p.109
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Therapeutic Effect of PLETAAL^(®), a New Platelet Aggregation Inhibitor with a Vasodilating Action, on Chronic Arterial Occlusive Diseases
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金基容/Kim, Key Yong
趙德衍/徐載昆/李重明/Cho, Duck Yun/Seo, Jai Gon/Lee, Jong Myung
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Abstract
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The clinical safety, efficacy of a new platelet aggregation inhibitor, cilostazol, with a vasodilating action in patients with chronic arterial occlusive disease accompanied by ischemic ulcer in the extremities were evaluated by administering the drug orally in daily doses of 2 00mg for 6 consecutive weeks in a open trial manner.
The assessment of global improvement of the disease made by the attending physician based on the improvement of ulcer, granuloma, rest pain and cold sensation indicated that the percent improvement based on the combined assessments of "Markedly improved" and "Improved" amounted to 53% and that based on the combined assessment of "Markedly mproved" "Improved" and "Slightly improved" amount to 88.67%.
The assessment of global utility of the drug evaluated by the attending physician based on the assessment of "Extremely useful" and "Useful" amuonted to 86.67%
Adverse reactions attributable to treatment with PLETAAL® were headache in 2 patients and upper abdominal pain in one patient, but these symptoms were not serious. Clinical laboratory values indicated no apparent changes attributable to treatment with the drug. The assessment of the overall safety of the drug was safe in 100% Based on these results, it was concluded that PLETAAL® was useful in the tr tment of chronic arterial occlusive disease accompanied by ischemic ulcer in the extremities at an optimal daily dose of 200mg.
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